Warhammer 40k, more or less with cogitators and servitors - no automation is allowed after an AI uprising tens of thousands of years ago. All processing is done by lobotomized and heavily modified humans. Many of these cybernetics are built into ships.
Ork FTL ships are built around the brain of an ork ‘weirdboy’ or psyker (sometimes).
I’m not too knowledgeable, but there are lots of edge cases. The machine spirits of the largest mechas (Titans) are known to have some autonomy and individual personalities, which is to say, they probably have some illicit AI or a less disabled human consciousness (-es) at their core.
https://warhammer40k.fandom.com/wiki/Titan