You might have issues with permissions for serial ports on some distros, but there are loads of easy to follow guides for that. Linux definitely handles them better than windows though. I never had issues where they just stop working like on Windows.
I use Fedora KDE, and I don’t think ive ever seen crashes that bad on my system (AMD CPU and GPU). I used to have a small problem with RADV crashing during video playback, but that solved itself after a few updates.